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Article

Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice.

Cardiovascular research - 1 Nov 2009

Zhuo Ming-Lei, Huang Yue, Chen Jing-Zhou, Sun Li-Hong, Yang Rui-Feng, Chen Hou-Zao, Lv Xiang, Li Hong-Liang, Wei Yu-Sheng, Liu Guang, Zhang Ran, Ma Tie-Min, Cai Hua, Hui Ru-Tai, Liu De-Pei, Liang Chih-Chuan

Abstract excerpt

AIMS: Hypertension is one of the major risk factors for cardiovascular diseases. Endothelial cells (ECs) exert important functions in the regulation of blood pressure. A novel gene, IC53, as an isoform of the cyclin-dependent kinase (CDK)-binding protein gene C53, is mainly expressed in vascular ECs and is upregulated in the failing heart of rats. Overexpression of IC53 promotes proliferation of ECs. To examine...

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Identifiers

PMID: 19541669
DOI: 10.1093/cvr/cvp204
PMCID: PMC6279175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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