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Article

Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury.

Circulation research - 11 Jun 2010

Naito Atsuhiko T, Okada Sho, Minamino Tohru, Iwanaga Koji, Liu Mei-Lan, Sumida Tomokazu, Nomura Seitaro, Sahara Naruhiko, Mizoroki Tatsuya, Takashima Akihiko, Akazawa Hiroshi, Nagai Toshio, Shiojima Ichiro, Komuro Issei

Abstract excerpt

RATIONALE: The number of patients with coronary heart disease, including myocardial infarction, is increasing and novel therapeutic strategy is awaited. Tumor suppressor protein p53 accumulates in the myocardium after myocardial infarction, causes apoptosis of cardiomyocytes, and plays an importa...

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Identifiers

PMID: 20413784
DOI: 10.1161/CIRCRESAHA.109.214346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20413784-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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