Article
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.
Bioorganic & medicinal chemistry - 15 Jul 2009
Büttner Anita, Seifert Katrin, Cottin Thomas, Sarli Vasiliki, Tzagkaroulaki Lito, Scholz Stefan, Giannis Athanassios
Abstract excerpt
Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. In vertebrates, the hh gene encodes three different unique proteins: sonic hedgehog (Shh), desert hedgehog (Dhh) and indian hedgehog (Ihh). Disruption of the Hh signaling pathway leads to severe disorders in the development of vertebrates whereas aberrant activation of the Hh pathway has been...
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