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Article

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2009

Hyman Joel M, Firestone Ari J, Heine Vivi M, Zhao Yun, Ocasio Cory A, Han Kyuho, Sun Mark, Rack Paul G, Sinha Surajit, Wu Jason J, Solow-Cordero David E, Jiang Jin, Rowitch David H, Chen James K

Abstract excerpt

Inappropriate activation of the Hedgehog (Hh) signaling pathway has been implicated in a diverse spectrum of cancers, and its pharmacological blockade has emerged as an anti-tumor strategy. While nearly all known Hh pathway antagonists target the transmembrane protein Smoothened (Smo), small mole...

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Identifiers

PMID: 19666565
DOI: 10.1073/pnas.0907134106
PMCID: PMC2721821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19666565-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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