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Article

Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese.

Neuroscience letters - 1 Dec 2000

Yang J D, Feng G, Zhang J, Lin Z X, Shen T, Breen G, St Clair D, He L

Abstract excerpt

There is now overwhelming evidence that the varepsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (I/D) DNA polymorphism at the intron...

Topics

Age Factors
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Case-Control Studies
China
Female
Genotype
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Odds Ratio

Peptidyl-Dipeptidase A

Polymorphism, Genetic

Source

Identifiers

PMID: 11078932
DOI: 10.1016/s0304-3940(00)01591-3

Genes

ACE
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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