Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association.

Abstract excerpt

BACKGROUND: Wilms tumor 1 (WT1) is a transcription factor that is overexpressed in most acute myeloid leukemias (AMLs). Recently, 2 groups reported that WT1 mutations occur in approximately 10% of normal karyotype AMLs and are an independent predictor of poor outcome in this subgroup of patients with AML. METHODS: The authors studied a cohort of 268 young adults (ages 15-50 years) with AML who were treated on the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adolescent
• Share to Genes, Wilms Tumor