Article
Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia.
Haematologica - 1 Jun 2010
Heesch Sandra, Goekbuget Nicola, Stroux Andrea, Tanchez Jutta Ortiz, Schlee Cornelia, Burmeister Thomas, Schwartz Stefan, Blau Olga, Keilholz Ulrich, Busse Antonia, Hoelzer Dieter, Thiel Eckhard, Hofmann Wolf-Karsten, Baldus Claudia D
Abstract excerpt
BACKGROUND: The role of the Wilms tumor 1 gene (WT1) in acute leukemias has been underscored by mutations found in acute myeloid leukemia identifying patients with inferior survival. Furthermore, aberrant expression of WT1 in acute myeloid leukemia was associated with an increased risk of relapse. No larger studies have performed a combined approach including WT1 mutation and expression analyses in acute...
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