Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party.

doi:10.1200/JCO.2008.16.0333

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Article

Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Nov 2008

Virappane Priya, Gale Rosemary, Hills Robert, Kakkas Ioannis, Summers Karin, Stevens Jane, Allen Christopher, Green Claire, Quentmeier Hilmar, Drexler Hans, Burnett Alan, Linch David, Bonnet Dominique, Lister T Andrew, Fitzgibbon Jude

Abstract excerpt

PURPOSE: To determine the clinical relevance of Wilms' tumor 1 (WT1) gene mutations in acute myeloid leukemia (AML) with normal karyotype (NK). PATIENTS AND METHODS: Exons 7 and 9 of WT1 were screened in samples from 470 young adult NK AMLs using a combination of direct sequencing and high-resolution capillary electrophoresis. RESULTS: Overall, 51 mutations were detected in 47 cases (10%): 46 frameshift mutations...

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Identifiers

PMID: 18591546
DOI: 10.1200/JCO.2008.16.0333

Genes

WT1
FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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