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Article

Disruption of protein kinase A in mice enhances healthy aging.

PloS one - 18 Jun 2009

Enns Linda C, Morton John F, Treuting Piper R, Emond Mary J, Wolf Norman S, Dai Dao-Fu, McKnight G S, Rabinovitch Peter S, Ladiges Warren C

Abstract excerpt

Mutations that cause a reduction in protein kinase A (PKA) activity have been shown to extend lifespan in yeast. Loss of function of mammalian RIIbeta, a regulatory subunit of PKA expressed in brain and adipose tissue, results in mice that are lean and insulin sensitive. It was therefore hypothesized that RIIB null (RIIbeta(-/-)) mice would express anti-aging phenotypes. We conducted lifespan studies using 40...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19536287
DOI: 10.1371/journal.pone.0005963
PMCID: PMC2693670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of protein kinase A in mice enhances healthy aging.PMID 19536287Read ↗

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