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Article

Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer.

British journal of cancer - 21 Jul 2009

Ryan A J, Napoletano S, Fitzpatrick P A, Currid C A, O'Sullivan N C, Harmey J H

Abstract excerpt

BACKGROUND: Insulin-like growth factor 1 (IGF1) promotes breast cancer and disease progression. Bioavailability of IGF1 is modulated by IGF-binding proteins (IGFBPs). IGFBP4 inhibits IGF1 activity but cleavage by pregnancy-associated plasma protein-A (PAPP-A) protease releases active IGF1. METHODS: Expression of IGF pathway components and PAPP-A was assessed by western blot or RT-PCR. IGFBP4 (dBP4) resistant to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mammary Neoplasms, Experimental

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Source

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Identifiers

PMID: 19536088
DOI: 10.1038/sj.bjc.6605141
PMCID: PMC2720214

Genes

IGF1
IGFBP4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer.PMID 19536088Read ↗

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