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Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activity in Vivo

8 Feb 2008

Abstract excerpt

IGFs are required for normal prenatal and postnatal growth. Although actions of IGFs can be modulated by a family of IGF-binding proteins (IGFBPs) in vitro, these studies have identified a complicated pattern of stimulatory and inhibitory IGFBP effects, so that understanding relevant aspects of IGFBP action in vivo has been limited. Here we have produced a null mutation of one specific IGFBP, IGFBP-4, which is...

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Genetic Syndromes and Imprinting
Growth Hormone and Insulin-like Growth Factors
Lipid metabolism and disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18258685
DOI: 10.1210/me.2007-0536

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