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Article

Expression of insulin‐like growth factor binding proteins in human breast cancer correlates with estrogen receptor status

1 Jun 1993

Abstract excerpt

The insulin-like growth factors (IGFs) have been implicated in the growth regulation of human breast cancer. Since the IGFs are associated with specific binding proteins (IGFBPs) which may modulate receptor/ligand interactions, production of IGFBPs by breast cancer cells could alter their IGF-dependent growth. This study examined the expression of IGFBPs 4, 5, and 6 in eight breast cancer cell lines (BCCLs) using...

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PMID: 7690042
DOI: 10.1002/jcb.240520211

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