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Article

Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4.

PloS one - 1 Jan 2011

Chander Harish, Halpern Max, Resnick-Silverman Lois, Manfredi James J, Germain Doris

Abstract excerpt

BACKGROUND: We previously reported that the degradation of prohibitin by the SCF(Skp2B) ubiquitin ligase results in a defect in the activity of p53. We also reported that MMTV-Skp2B transgenic mice develop mammary gland tumors that are characterized by an increased proteolytic cleavage of the insulin-like growth factor binding protein 4 (IGFBP-4), an inhibitor of IGF signaling. However, whether a link exists...

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Identifiers

PMID: 21829624
DOI: 10.1371/journal.pone.0022456
PMCID: PMC3150379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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