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Article

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles.

Nucleic acids research - 1 Jan 2004

Miller Victor M, Gouvion Cynthia M, Davidson Beverly L, Paulson Henry L

Abstract excerpt

Tau and amyloid precursor protein (APP) are key proteins in the pathogenesis of sporadic and inherited Alzheimer's disease. Thus, developing ways to inhibit production of these proteins is of great research and therapeutic interest. The selective silencing of mutant alleles, moreover, represents an attractive strategy for treating inherited dementias and other dominantly inherited disorders. Here, using tau and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14754988
DOI: 10.1093/nar/gkh208
PMCID: PMC373334

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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