Article
Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects.
PloS one - 1 Jan 2011
Chakraborty Ranjita, Vepuri Vidya, Mhatre Siddhita D, Paddock Brie E, Miller Sean, Michelson Sarah J, Delvadia Radha, Desai Arkit, Vinokur Marianna, Melicharek David J, Utreja Suruchi, Khandelwal Preeti, Ansaloni Sara, Goldstein Lee E, Moir Robert D, Lee Jeremy C, Tabb Loni P, Saunders Aleister J, Marenda Daniel R
Abstract excerpt
Transgenic models of Alzheimer's disease (AD) have made significant contributions to our understanding of AD pathogenesis, and are useful tools in the development of potential therapeutics. The fruit fly, Drosophila melanogaster, provides a genetically tractable, powerful system to study the biochemical, genetic, environmental, and behavioral aspects of complex human diseases, including AD. In an effort to model...
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