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Article

Is there a role for mannan-binding lectin in the diagnosis of inflammatory bowel disease?

Immunogenetics - 1 Apr 2010

Hoffmann Christina, Hoffmann Peter, Lun Andreas, Büning Carsten, Hiepe Falk, Scherer Hans U, Steinhagen-Thiessen Elisabeth, Weimann Andreas

Abstract excerpt

Mannan-binding lectin (MBL) activates the lectin-complement pathway as part of the innate immune defence by binding to the surface of microorganisms. Therefore, MBL2 presents an interesting candidate gene for the inflammatory bowel diseases, ulcerative colitis (UC) and Crohn's disease (CD). In our study, we evaluated the MBL serum concentrations and genotypes for diagnostic and classification purposes of patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20182871
DOI: 10.1007/s00251-010-0429-0

Genes

MBL2
NOD2

Variants

Provenance

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