Article
Aberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Nov 2009
Lin Xiaojie, Ding Jiaxiang, Zhu Li, Shi Sufang, Jiang Lei, Zhao Minghui, Zhang Hong
Abstract excerpt
BACKGROUND: Immunoglobulin A nephropathy (IgAN) is associated with genetic and environmental factors, and undergalactosylation of IgA1 in the serum is considered to be a contributor to pathogenesis of IgAN. The present study was conducted to detect the galactose- (Gal) deficient IgA1 level in Chinese IgAN patients and their family members. METHODS: Sixty-three IgAN patients were enrolled, where 32 first-degree...
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