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Article

MDM2 309 polymorphism predicts outcome in platinum-treated locally advanced head and neck cancer.

Oral oncology - 1 Jul 2012

Vivenza Daniela, Gasco Milena, Monteverde Martino, Lattanzio Laura, Syed Nelofer, Colantonio Ida, Denaro Nerina, Natoli Guido, Comino Alberto, Russi Elvio, Merlano Marco, Crook Tim, Lo Nigro Cristiana

Abstract excerpt

Chemo-radiotherapy (CRT) with cisplatin-based regimens is curative in a subset of patients with locally advanced (stage III and IV) squamous carcinomas of the head and neck (LAHNSCC), but causes considerable toxicity. To seek predictive biomarkers, we analysed single nucleotide polymorphisms (SNPs) in the p53 and MDM2 genes in LAHNSCC patients treated with cisplatin-based CRT. We analysed germ-line p53 72 Arg/Pro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22356895
DOI: 10.1016/j.oraloncology.2012.01.022

Genes

MDM2
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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