Article
MDM2 SNP309 genotype is associated with ferritin and LDH serum levels in children with stage 4 neuroblastoma.
Pediatric blood & cancer - 1 Aug 2010
Parodi Stefano, Perfumo Chiara, Garaventa Alberto, Inga Alberto, Mazzocco Katia, Defferrari Raffaella, Tonini Gian Paolo, Fronza Gilberto, Haupt Riccardo
Abstract excerpt
BACKGROUND: MDM2 SNP309, characterised by a T-to-G substitution in the MDM2 promoter, is associated with higher gene expression compared to wild type and was recently found to be a negative prognostic factor for patients with stage 4 neuroblastoma (NB), but not for children with localised disease. This polymorphism was not associated with any clinical or genetic tumour characteristics, including MYCN...
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