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Article

NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation

15 Feb 2023

Abstract excerpt

The origin and differentiation mechanism of articular chondrocytes remain poorly understood. Broadly, the difference in developmental mechanisms of articular and growth-plate cartilage is still less elucidated. Here, we identified that the nuclear factor of activated T-cells cytoplasmic 1 (NFATc1) is a crucial regulator of articular, but not growth-plate, chondrocyte differentiation during development. At the...

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PMID: 36790146
DOI: 10.7554/elife.81569

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