Osteoarthritis: genetic factors, animal models, mechanisms, and therapies.

Abstract excerpt

Osteoarthritis (OA) is the most common form of joint disease. OA frequently affects knees, hips, hands, and the spine. It is characterized by the progressive destruction of articular cartilage and subchondral bone accompanied by low-grade inflammation that together result in pain and deformity. Recent studies have shed light on the nature of OA genetic susceptibility and confirmed a number of candidate genes...

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• Disease Models, Animal
• Genetic Predisposition to Disease
• Osteoarthritis