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Article

Inhibition of BATF/JUN transcriptional activity protects against osteoarthritic cartilage destruction

5 May 2016

Abstract excerpt

OBJECTIVE: The basic leucine zipper transcription factor, ATF-like (BATF), a member of the Activator protein-1 family, promotes transcriptional activation or repression, depending on the interacting partners (JUN-B or C-JUN). Here, we investigated whether the BATF/JUN complex exerts regulatory effects on catabolic and anabolic gene expression in chondrocytes and contributes to the pathogenesis of osteoarthritis...

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PMID: 27147707
DOI: 10.1136/annrheumdis-2015-208953

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