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Transcriptional regulation of bone and joint remodeling by NFAT

23 Dec 2009

Abstract excerpt

Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture-prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that...

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PMID: 20193006
DOI: 10.1111/j.0105-2896.2009.00849.x

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