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Article

Parkin gene modifies the effect of RLS4 on the age at onset of restless legs syndrome (RLS).

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2010

Pichler Irene, Marroni Fabio, Pattaro Cristian, Lohmann Katja, de Grandi Alessandro, Klein Christine, Hicks Andrew A, Pramstaller Peter P

Abstract excerpt

A co-occurrence of restless legs syndrome (RLS) and Parkin mutations has been described. In South Tyrolean RLS patients, a novel RLS locus has been found (RLS4) and recurrent Parkin mutations have been reported. By a systematic screen we investigated the presence of founder Parkin mutations in South Tyrolean RLS patients with known carrier status at the RLS4 locus and assessed whether these mutations alone or in...

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Identifiers

PMID: 19526454
DOI: 10.1002/ajmg.b.30988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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