Article
Co-occurrence of restless legs syndrome and Parkin mutations in two families.
Movement disorders : official journal of the Movement Disorder Society - 1 Feb 2006
Adel Susanna, Djarmati Ana, Kabakci Kemal, Pichler Irene, Eskelson Cordula, Lohnau Thora, Kock Norman, Hagenah Johann, Hedrich Katja, Schwinger Eberhard, Kramer Patricia L, Pramstaller Peter P, Klein Christine
Abstract excerpt
Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance...
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