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Article

Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families.

Annals of neurology - 1 Sept 2002

Winkelmann Juliane, Muller-Myhsok Bertram, Wittchen Hans-Ulrich, Hock Bettina, Prager Muriel, Pfister Hildegard, Strohle Andreas, Eisensehr Ilonka, Dichgans Martin, Gasser Thomas, Trenkwalder Claudia

Abstract excerpt

A strong familial component of restless legs syndrome (RLS) is known. The objective of this study therefore was to investigate the likely mode of inheritance of RLS. RLS patients and their first-degree relatives were investigated and classified in RLS affected and RLS nonaffected subjects. Assessments were based on direct, personal standardized diagnostic interviews. Complex segregation analysis was performed...

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Identifiers

PMID: 12205641
DOI: 10.1002/ana.10282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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