Article
An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.
Oncogene - 6 Aug 2009
Chitale D, Gong Y, Taylor B S, Broderick S, Brennan C, Somwar R, Golas B, Wang L, Motoi N, Szoke J, Reinersman J M, Major J, Sander C, Seshan V E, Zakowski M F, Rusch V, Pao W, Gerald W, Ladanyi M
Abstract excerpt
To address the biological heterogeneity of lung cancer, we studied 199 lung adenocarcinomas by integrating genome-wide data on copy number alterations and gene expression with full annotation for major known somatic mutations in this cancer. This showed non-random patterns of copy number alterations significantly linked to EGFR and KRAS mutation status and to distinct clinical outcomes, and led to the discovery...
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