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Article

Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2017

George Julie, Saito Motonobu, Tsuta Koji, Iwakawa Reika, Shiraishi Kouya, Scheel Andreas H, Uchida Shinsuke, Watanabe Shun-Ichi, Nishikawa Ryo, Noguchi Masayuki, Peifer Martin, Jang Se Jin, Petersen Iver, Büttner Reinhard, Harris Curtis C, Yokota Jun, Thomas Roman K, Kohno Takashi

Abstract excerpt

Purpose: Programmed death ligand-1 (PD-L1), encoded by the CD274 gene, is a target for immune checkpoint blockade; however, little is known about genomic CD274 alterations. A subset of small-cell lung cancer (SCLC) exhibits increased copy number of chromosome 9p24, on which CD274 resides; however, most SCLCs show low expression of PD-L1. We therefore examined whether CD274 is a target of recurrent genomic...

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Share to B7-H1 Antigen
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 9

Share to DNA Copy Number Variations

Share to Gene Amplification

Share to Gene Expression Regulation, Neoplastic

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

Source

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Identifiers

PMID: 27620277
DOI: 10.1158/1078-0432.CCR-16-1069
PMCID: PMC6329376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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