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Article

RAS signaling in lung adenocarcinoma is defined by lineage context and DUSP4 loss.

JCI insight - 22 Apr 2026

Kim Minjeong, Lamlertthon Wisut, Jo Heejoon, Cui Yan, Yeon Miyeon, Choi Hyo Young, Hoadley Katherine A, Smeltzer Matthew P, Hayward Michele C, Wilkerson Matthew D, Makowski Liza, Hayes D Neil

Abstract excerpt

BACKGROUNDThe molecular landscape of lung adenocarcinoma (LUAD) is often illustrated as a driver-oncogene pie chart, but identical mutations exhibit heterogeneous signaling shaped by comutations, transcriptional programs, and lineage context. We propose a lineage-integrated signaling framework using an EGFR mutation signature (mSig).METHODSWe defined EGFR mSig using differentially expressed genes in EGFR-mutant...

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Share to Adenocarcinoma of Lung
Share to Dual-Specificity Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 41817586
DOI: 10.1172/jci.insight.200912
PMCID: PMC13135389

Genes

EGFR
TP53
CDKN2A
DUSP4
KEAP1
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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