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Article

Identification of a major susceptibility locus for lethal graft-versus-host disease in MHC-matched mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2009

Cao Thai M, Lazzeroni Laura C, Tsai Schickwann, Pang Wendy W, Kao Amy, Camp Nicola J, Thomas Alun, Shizuru Judith A

Abstract excerpt

Graft-vs-host disease (GVHD) is the major cause of morbidity and mortality after allogeneic hemopoietic cell transplantation. From a genetic perspective, GVHD is a complex phenotypic trait. Although it is understood that susceptibility results from interacting polymorphisms of genes encoding histocompatibility Ags and immune regulatory molecules, a detailed and integrative understanding of the genetic background...

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Identifiers

PMID: 19525392
DOI: 10.4049/jimmunol.0900454
PMCID: PMC2735236

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