Article
Identification of a major susceptibility locus for lethal graft-versus-host disease in MHC-matched mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2009
Cao Thai M, Lazzeroni Laura C, Tsai Schickwann, Pang Wendy W, Kao Amy, Camp Nicola J, Thomas Alun, Shizuru Judith A
Abstract excerpt
Graft-vs-host disease (GVHD) is the major cause of morbidity and mortality after allogeneic hemopoietic cell transplantation. From a genetic perspective, GVHD is a complex phenotypic trait. Although it is understood that susceptibility results from interacting polymorphisms of genes encoding histocompatibility Ags and immune regulatory molecules, a detailed and integrative understanding of the genetic background...
Topics
- Animals
- Crosses, Genetic
- Female
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Graft vs Host Disease
- H-2 Antigens
- Histocompatibility Testing
- Immunity, Innate