Article
Fine mapping of the Bmgr5 quantitative trait locus for allogeneic bone marrow engraftment in mice.
Immunogenetics - 1 Aug 2013
Wang Yuanyuan, Chen Xinjian, Tsai Schickwann, Thomas Alun, Shizuru Judith A, Cao Thai M
Abstract excerpt
To identify novel mechanisms regulating allogeneic hematopoietic cell engraftment, we used forward genetics and previously described identification, in mice, of a bone marrow (BM) engraftment quantitative trait locus (QTL), termed Bmgr5. This QTL confers dominant and large allele effects for engraftment susceptibility. It was localized to chromosome 16 by quantitative genetic techniques in a segregating backcross...
Topics
- Alleles
- Animals
- Bone Marrow
- Bone Marrow Transplantation
- Chromosome Mapping
- Chromosomes, Mammalian
- Exome
- Female
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Male
- Mice
- Mice, Congenic
- Mice, Inbred BALB C