Article
Genetic factors influencing the development of chronic graft-versus-host disease in a murine model.
Bone marrow transplantation - 1 Nov 2000
Slayback D L, Dobkins J A, Harper J M, Allen R D
Abstract excerpt
Graft-versus-host disease (GVHD) is a major complication of bone marrow transplantation that can occur in either acute or chronic forms. Much of the long-term pathology seen in chronic GVHD is a result of autoantibody production. In the DBA/2-->B6D2F1 murine model of chronic GVHD, anti-ssDNA autoantibodies can be detected by 14 days post cell transfer. These autoantibodies are not observed in B6D2F1 recipients of...
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