Article
Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation.
Archives of neurology - 1 May 1997
Almkvist O, Basun H, Wagner S L, Rowe B A, Wahlund L O, Lannfelt L
Abstract excerpt
OBJECTIVE: To explore the relationship between possible biological markers of Alzheimer disease that are related to amyloid metabolism and mental functions. PARTICIPANTS: Twelve individuals from a Swedish family with Alzheimer disease and a double mutation at codons 670/671 of the amyloid precurs...
Topics
- Adult
- Aged
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Aspartic Acid Endopeptidases
- Cognition
- Endopeptidases
- Female
- Genes
- Humans
- Male
- Middle Aged
- Mutation
- Neuropsychological Tests
- Solubility