Article
Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition.
Neurobiology of aging - 1 Jan 2000
Ishii K, Lippa C, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser P E, Shoji S, Nee L E, Pollen D A, St George-Hyslop P H, Ii K, Ohtake T, Kalaria R N, Rossor M N, Lantos P L, Cairns N J, Farrer L A, Mori H
Abstract excerpt
Both APP and PS-1 are causal genes for early-onset familial Alzheimer's disease (AD) and their mutation effects on cerebral Abeta deposition in the senile plaques were examined in human brains of 29 familial AD (23 PS-1, 6 APP) cases and 14 sporadic AD cases in terms of Abeta40 and Abeta42. Abeta isoform data were evaluated using repeated measures analysis of variance which adjusted for within-subject measurement...
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