Article
Stromelysin-1 polymorphism as a new potential risk factor in progression of chronic obstructive pulmonary disease.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace - 1 Mar 2009
Santus P, Casanova F, Biondi M L, Blasi F, Di Marco F, Centanni S
Abstract excerpt
BACKGROUND: Chronic obstructive lung disease (COPD) is characterised by partially reversible usually progressive airflow limitation caused by inflammation and remodelling. Stromelysin-1 (MMP-3) has regulatory activity on other matrix-metalloproteinases. Altered MMP-3 activity has been described in different diseases. We investigated the role of a promoter MMP-3 polymorphism in determining susceptibility and...
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