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Article

Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate.

The European respiratory journal - 1 Apr 2010

van Diemen C C, Postma D S, Aulchenko Y S, Snijders P J L M, Oostra B A, van Duijn C M, Boezen H M

Abstract excerpt

Studies using genetic isolates with limited genetic variation may be useful in chronic obstructive pulmonary disease (COPD) genetics, but are thus far lacking. The associations between single nucleotide polymorphisms (SNPs) in candidate genes and lung function in COPD were studied in a genetic isolate. In 91 subjects with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage >or=1 COPD, who were...

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Source

Identifiers

PMID: 19797132
DOI: 10.1183/09031936.00054408

Genes

FEV
TGFB1
SFTPA1
SFTPD
SFTPA2
ADAM33
GSTP1
HMOX1
MMP1
MMP12
MMP2
MMP9
SFTPB
TIMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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