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Article

Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice.

International journal of cancer - 15 Nov 2006

McAlpine Christen A, Barak Yaacov, Matise Ilze, Cormier Robert T

Abstract excerpt

Multiple investigations of the effects of peroxisome proliferator-activated receptor gamma (PPARgamma) ligands on colon cancer have produced contradictory results. While some studies demonstrated increased numbers of colonic polyps in Apc(Min/+) mice treated with various thiazolidinedione (TZD) PPARgamma ligands, others reported amelioration of tumor multiplicity and progression in both Apc(Min/+) mice and in...

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Source

Identifiers

PMID: 16858678
DOI: 10.1002/ijc.22115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice.PMID 16858678Read ↗

Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.Semantic proximity Read ↗

APC-dependent suppression of colon carcinogenesis by PPARgamma.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice.Semantic proximity Read ↗

Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and InvasionSemantic proximity Read ↗

PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo.Semantic proximity Read ↗

Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min‐FCCC) mice with significantly increased numbers of colorectal adenomasSemantic proximity Read ↗

The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.Semantic proximity Read ↗

Wnt and Cyclooxygenase-2 Cross-talk Accelerates Adenoma GrowthSemantic proximity Read ↗

Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ MiceSemantic proximity Read ↗

Widespread hyperplasia induced by transgenic TGFalpha in ApcMin mice is associated with only regional effects on tumorigenesis.Semantic proximity Read ↗

The role of peroxisome proliferator-activated receptor gamma in colon cancer and inflammatory bowel disease.Semantic proximity Read ↗

Induction of inflammatory bowel disease accelerates adenoma formation in Min +/- mice.Semantic proximity Read ↗

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