Article
Epidermal growth factor A61G gene polymorphism, gastroesophageal reflux disease and esophageal adenocarcinoma risk.
Carcinogenesis - 1 Aug 2009
Cheung Winson Y, Zhai Rihong, Kulke Matthew H, Heist Rebecca S, Asomaning Kofi, Ma Clement, Wang Zhaoxi, Su Li, Lanuti Michael, Tanabe Kenneth K, Christiani David C, Liu Geoffrey
Abstract excerpt
BACKGROUND: Single-nucleotide polymorphisms of key cancer genes, such as EGF A61G, are associated with an elevated risk of esophageal adenocarcinoma (EAC). As gastroesophageal reflux disease (GERD) is an established risk factor for EAC, we evaluated whether the association between epidermal growth factor (EGF) polymorphism and EAC development is altered by the presence of GERD. METHODS: EGF genotyping of DNA...
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