Article
Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study.
Disease markers - 1 Jan 2022
Deissova Tereza, Cvanova Michaela, Kala Zdenek, Jiraskova Zakostelska Zuzana, Dolina Jiri, Kunovsky Lumir, Kroupa Radek, Pavlovsky Zdenek, Lipovy Bretislav, Danek Zdenek, Izakovicova Holla Lydie, Urban Ondrej, Navratil Vit, Lischke Robert, Harustiak Tomas, Grolich Tomas, Prochazka Vladimir, Slaby Ondrej, Borilova Linhartova Petra
Abstract excerpt
The epidermal growth factor (EGF) and its receptor (EGFR) gene-gene interactions were shown to increase the susceptibility to esophageal cancer. However, the role of the EGF/EGFR pathway in the development of gastroesophageal reflux disease (GERD) and its complications (reflux esophagitis (RE), Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC)) remains unclear. This association study is aimed at...
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