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Article

Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett's esophagus and esophageal adenocarcinoma.

Journal of human genetics - 1 Jan 2012

Menke Vivianda, Pot Raymond G J, Moons Leon M G, van Zoest Katinka P M, Hansen Bettina, van Dekken Herman, Siersema Peter D, Kusters Johannes G, Kuipers Ernst J

Abstract excerpt

Reflux esophagitis (RO) and Barrett's esophagus (BO) can cause esophageal adenocarcinoma (OAC). The esophageal mucosa in the RO-BO-OAC cascade is chronically exposed to gastro-esophageal reflux. Epidermal growth factor (EGF) has an important role in the protection and repair of mucosal damage, and non-physiologic levels are associated with gastrointestinal tumors. The aim is to determine the functional effect of...

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Identifiers

PMID: 22129558
DOI: 10.1038/jhg.2011.124

Genes

EGF

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Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett's esophagus and esophageal adenocarcinoma.PMID 22129558Read ↗

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