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Article

Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.

Investigative ophthalmology & visual science - 1 Oct 2009

Martinez Gemma, Wijesinghe Mary, Turner Kirsty, Abud Helen E, Taketo Makoto M, Noda Tetsuo, Robinson Michael L, de Iongh Robb U

Abstract excerpt

PURPOSE: Previous studies indicate that the Wnt/beta-catenin-signaling pathway is active and functional during murine lens development. In this study, the consequences of constitutively activating the pathway in lens during development were investigated. METHODS: To activate Wnt/beta-catenin signaling, beta-catenin (Catnb) and adenomatous polyposis coli (Apc) genes were conditionally mutated in two Cre lines that...

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Source

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PMID: 19515997
DOI: 10.1167/iovs.09-3567

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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