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Article

Global Gene Expression Analysis of Reactive Stroma in Prostate Cancer

15 Jun 2009

Abstract excerpt

PURPOSE: Marked reactive stroma formation, designated as grade 3 reactive stroma, is associated with poor outcome in clinically localized prostate cancer. To understand the biological processes and signaling mechanisms underlying the formation of such reactive stroma, we carried out microarray gene expression analysis of laser-captured reactive stroma and matched normal stroma. EXPERIMENTAL DESIGN: Seventeen...

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PMID: 19509179
DOI: 10.1158/1078-0432.ccr-08-1899

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