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Article

Expression Changes in the Stroma of Prostate Cancer Predict Subsequent Relapse

1 Aug 2012

Abstract excerpt

Biomarkers are needed to address overtreatment that occurs for the majority of prostate cancer patients that would not die of the disease but receive radical treatment. A possible barrier to biomarker discovery may be the polyclonal/multifocal nature of prostate tumors as well as cell-type heterogeneity between patient samples. Tumor-adjacent stroma (tumor microenvironment) is less affected by genetic alteration...

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PMID: 22870216
DOI: 10.1371/journal.pone.0041371

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