Genes Upregulated in Prostate Cancer Reactive Stroma Promote Prostate Cancer Progression In Vivo

Abstract excerpt

PURPOSE: Marked reactive stroma formation is associated with poor outcome in clinically localized prostate cancer. We have previously identified genes with diverse functions that are upregulated in reactive stroma. This study tests the hypothesis that expression of these genes in stromal cells enhances prostate cancer growth in vivo. EXPERIMENTAL DESIGN: The expression of reactive stroma genes in prostate stromal...

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