Article
A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.
Journal of medical genetics - 1 Sept 2009
Zhai G, van Meurs J B J, Livshits G, Meulenbelt I, Valdes A M, Soranzo N, Hart D, Zhang F, Kato B S, Richards J B, Williams F M K, Inouye M, Kloppenburg M, Deloukas P, Slagboom E, Uitterlinden A, Spector T D
Abstract excerpt
To identify the susceptibility gene in hand osteoarthritis (OA) the authors used a two-stage approach genome-wide association study using two discovery samples (the TwinsUK cohort and the Rotterdam discovery subset; a total of 1804 subjects) and four replication samples (the Chingford Study, the Chuvasha Skeletal Aging Study, the Rotterdam replication subset and the Genetics, Arthrosis, and Progression (GARP)...
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