Article
The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.
Haematologica - 1 Dec 2014
Durinck Kaat, Wallaert Annelynn, Van de Walle Inge, Van Loocke Wouter, Volders Pieter-Jan, Vanhauwaert Suzanne, Geerdens Ellen, Benoit Yves, Van Roy Nadine, Poppe Bruce, Soulier Jean, Cools Jan, Mestdagh Pieter, Vandesompele Jo, Rondou Pieter, Van Vlierberghe Pieter, Taghon Tom, Speleman Frank
Abstract excerpt
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T-cell acute lymphoblastic leukemias, supporting a role as an essential driver for this gene in T-cell acute...
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