Structure is three to ten times more conserved than sequence--a study of structural response in protein cores.

Abstract excerpt

Protein structures change during evolution in response to mutations. Here, we analyze the mapping between sequence and structure in a set of structurally aligned protein domains. To avoid artifacts, we restricted our attention only to the core components of these structures. We found that on average, using different measures of structural change, protein cores evolve linearly with evolutionary distance (amino...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amino Acids
• Share to Conserved Sequence
• Share to Databases, Protein