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Article

The combined effects of amino acid substitutions and indels on the evolution of structure within protein families.

PloS one - 13 Dec 2010

Zhang Zheng, Wang Yuxiao, Wang Lushan, Gao Peiji

Abstract excerpt

BACKGROUND: In the process of protein evolution, sequence variations within protein families can cause changes in protein structures and functions. However, structures tend to be more conserved than sequences and functions. This leads to an intriguing question: what is the evolutionary mechanism by which sequence variations produce structural changes? To investigate this question, we focused on the most common...

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Identifiers

PMID: 21179197
DOI: 10.1371/journal.pone.0014316
PMCID: PMC3001449

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