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Article

Decomposing Structural Response Due to Sequence Changes in Protein Domains with Machine Learning.

Journal of molecular biology - 24 Jul 2020

Bryant Patrick, Elofsson Arne

Abstract excerpt

How protein domain structure changes in response to mutations is not well understood. Some mutations change the structure drastically, while most only result in small changes. To gain an understanding of this, we decompose the relationship between changes in domain sequence and structure using machine learning. We select pairs of evolutionarily related domains with a broad range of evolutionary distances. In...

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Identifiers

PMID: 32485208
DOI: 10.1016/j.jmb.2020.05.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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