Article
Gene set-based analysis of polymorphisms: finding pathways or biological processes associated to traits in genome-wide association studies.
Nucleic acids research - 1 Jul 2009
Medina Ignacio, Montaner David, Bonifaci Nuria, Pujana Miguel Angel, Carbonell José, Tarraga Joaquin, Al-Shahrour Fatima, Dopazo Joaquin
Abstract excerpt
Genome-wide association studies have become a popular strategy to find associations of genes to traits of interest. Despite the high-resolution available today to carry out genotyping studies, the success of its application in real studies has been limited by the testing strategy used. As an alternative to brute force solutions involving the use of very large cohorts, we propose the use of the Gene Set Analysis...
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